Correlations between the Periodontal Modifications and Lipid Peroxidation in Periodontal Disease Patients

The purpose of the study Our study was centred on the comparative research of enzymatic and non-enzymatic oxidative status mediators in the crevicular fluid on chronic and aggressive periodontitis patients, compared to periodontal healthy subjects. Materials and methods The study was conducted on 42 patients. They were divided in 3 study groups: chronic periodontitis subjects, aggressive periodontitis patients and periodontal healthy subjects. On marginal periodontitis patients, associated or not with systemic diseases, we initially collected gingival crevicular fluid and saliva samples and we evaluated the following enzymatic stress markers for all the three groups of subjects: superoxide dismutase, glutathione peroxidase, malondialdehyde, using the gingival crevicular fluid (GCF) as biologic material. Results The statistical analysis for the malondialdehyde in the control group, aggressive periodontitis group and chronic periodontitis group shows significant differences between the groups. SOD values in the gingival crevicular fluid were low in the periodontitis groups compared to the control group. Despite the strong correlation between the glutathione peroxidase values in the three groups, we did not observe any significant differences between the GPx values in the aggressive periodontitis, chronic periodontitis and control groups. Conclusions The present study revealed significant statistic differences between most of the oxidative stress parameters analysed in the GCF, especially in the aggressive periodontitis group, less in the chronic periodontitis group compared to the control group. Key-words: oxidative status, chronic periodontitis, aggressive periodontitis